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The combination of repulsion and steric constraints is thought to remove the X-Y linker from near the active site and relieve auto-inhibition

BCAA supplementation during exercise can help to competitively inhibit tryptophan transport into the brain, lowers brain tryptophan uptake and serotonin synthesis which prevents or delays the onset of central fatigue during prolonged, intense workouts

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A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

One drug, lomitapide (Juxtapid), is a small molecule inhibitor of the microsomal triglyceride transfer protein (MTTP

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