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Beyond its role in fatty acid metabolism, L-Carnitine functions as an acyl group acceptor that facilitates mitochondrial export of excess carbons in the form of acylcarnitines, preventing the accumulation of toxic metabolic intermediates

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& Buhr, K

These dual activities make PGC-1 an almost ideal target protein to control or limit the damage associated with defective mitochondrial function in neurodegenerative diseases

doi: 10.1093/aje/kwn250
