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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

Specifically, glutaredoxin protects thiols by the transfer of electrons from NADPH to disulfide substrates and this cycle is connected with glutathione and glutathione reductase (48)

Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies

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Dehydration is also a common problem due to illness, surgery and other factors