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Compared with normal animals, Nrf2-deficient mice have more pronounced effects on lipopolysaccharide (LPS)-induced microglial activation and inflammatory response, with lower levels of IL-1, IL-6, IL-12, and TNF- in the brain ( Moreover, increasing evidence indicated that Nrf2 may regulate mitochondrial function and metabolism

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Lee MJ, Su YN, You HL, Chiou SC, Lin LC, Yang CC, et al

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Mol Cell Endocrinol