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In vitro studies

So far, at least five protein families have been implicated in cellular choline uptake in humans (Fig 1B): the high-affinity choline transporter family (CHT, SLC5) (15), the organic cation transporter family (OCT, SLC22) (16), the mitochondrial carrier family (MCF, SLC25) (10), the choline transporter-like family (CTL, SLC44) (17), and the feline leukemia virus subgroup C receptorrelated family (FLVCR, SLC49) (18)

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[24] Therefore, PIP 2 depletion by the PLC reaction is critical to the regulation of local PIP 3 concentrations both in the plasma membrane and the nuclear membrane