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For example, opioids decrease pulmonary perfusion via hypoxia-induced pulmonary vasoconstriction 143 , and by direct pulmonary vasoconstriction 144,145 by mechanisms including centrally-mediated activation of sympathetic nerve activity to the lungs 146 , and induction of histamine release in the lungs 144,147

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For example, the VPA-induced rat model is characterized by reduced oxytocin mRNA levels, fewer oxytocin-immunoreactive cell numbers in the paraventricular nucleus, and lower oxytocin concentration in the cerebrospinal fluid [31]

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