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Over the course of the human organisms existence, the microbial community adjusts to these stimuli, adapting accordingly

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These data suggest that ghrelin may aid in two ways: (1) by amplifying the remaining dopaminergic signaling through the D1R-GHSR1a dimer, and (2) by providing neuroprotective effects that may aid in slowing the progression of further dopaminergic degeneration, which may be the result of GHSR signaling alone

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10.2337/db24-0177 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Scheithauer TPM, Herrema H, Yu H et al (2022) Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction