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In addition, baicalein (BAE) and DOX were separately loaded into cationic solid lipid nanoparticles to form BAE-SLN and DOX-SLN, where BAE-SLN was modified with aminoethyl aniline amide (AEAA) to form AEAA-BAE-SLN (ABS) and DOX-SLN was modified with folic acid (FA) to form FA-DOX-SLN (FDS), and both were further encapsulated in carboxymethyl chitosan (CMCS) to form the nanocapsule NPC-ABS/FDS which can enhance CD8 + T and CD4 + T cells infiltration, reduce Tregs, and significantly inhibit tumor growth (165)

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For example, a study conducted by Hsieh et al

For example, curcumin is notoriously poorly bioavailable: in animal studies, only nanogramlevel concentrations of curcumin appear in plasma after oral dosing, and in humans even doses as high as 8 g orally can result in undetectable or extremely low plasma levels [36]

Wei J, Feng J

Blood samples were collected at Baseline (Day 0), Day 3, and Day 7