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Nat Rev Immunol 2(5):364371 Tseng WY et al (2018) High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis

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Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant

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In order to be taken up by the liver it has to be degraded to amino acids. [I also wonder- since glutamate is elevated in metabolic disease, and a residue in the GSH tripeptide, might it be that providing glycine or serine to support synthesis could be preferred over glutathione