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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

A quick, honest caveat Every sign above is also seen in far more common conditions: iron-deficiency anaemia, hypothyroidism, poor sleep, vitamin D or B12 deficiency, and depression, among others

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Recent studies have highlighted the ability of SARS-CoV-2 proteins to interfere with key intracellular pathways, including autophagy, mitochondrial dynamics, oxidative and nitrosative stress responses, calcium signaling, and the regulation of transcription factors such as HIF-1 and Nrf2 (311)

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