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This manipulation produced a risk-avoidance phenotype in mice and promoted alcohol anxiolytic effects, from the very first exposure to alcohol, suggesting these behaviors are the consequence of a preexisting imbalance in striatal dopamine receptor levels

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The permeability of the NMDAR pore to the predominant intracellular and extracellular monovalent cations K + and Na + , respectively results in depolarization from the normal resting membrane potential of CNS neurons

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