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Glutaminase isoenzymes can exert contrary functions As mentioned above, the first step of Gln degradation is catalyzed by glutaminase (GLA)

Dysbiosis can lead to the activation of pro-inflammatory pathways, such as the NF-B pathway, which in turn increases the production of cytokines and inflammatory mediators that compromise the BBB (Sanz and De Palma, 2009)

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This points to the lasting impact of early-life iron deficiency on brain function and its potential to contribute to psychiatric disorders