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Minoxidil increases 17b-hydroxysteroid dehydrogenase and 5a-reductase activity of cultured human dermal papilla cells from balding scalp

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doi: 10.1038/s41586-018-0079-1

Shichi H, Somers RL (1978) Light-dependent phosphorylation of rhodopsin

To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)

Both things are true