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Additionally, accumulation of cyanocobalamin metabolites may occur in severe renal impairment, though this is rarely clinically significant

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The SA may actually perform these duties for the ISSM, however, the ISSM still maintains responsibility
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The 20mg blend vial is typically reconstituted with 2-4 ml of bacteriostatic water, giving a combined concentration of 10 mg/ml or 5 mg/ml

doi: 10.1016/j.cortex.2014.05.003, 93 RuegseggerG
