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Redox-inactive Fe 3+ in the circulation was bound by the iron carrier, transferrin (Tf), and subsequently taken up by Tf receptor (TfR)-mediated endocytosis, delivering iron to tissues and organs [23]
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It regulates fibroblast behavior, gene expression, and remodeling dynamics, indirectly influencing collagen deposition and tissue architecture without becoming a physical part of the extracellular matrix

it also plays a vital role in tissues such as the skin and brain

Free Radical Biol Med 14:303311 [DOI] [PubMed] [Google Scholar] Carocho M, Ferreira ICFR (2013) A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives

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