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Significant decreases were observed in GABBR1, GABBR2, GABRA1, and GABRB3

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For example, selective FGFR4 agonism, either peripherally or in liver, does not affect fasting glucose in obese diabetic mice, but increases triglycerides and total cholesterol (307, 308)

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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations