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In older children or adults it may be considered if there are clinical symptoms suggestive of carnitine deficiency (hypotonia, lethargy), a significant decrease in the serum free carnitine levels, an impairment in hepatic function tests, or hyperammonaemia, even in the absence of VHE

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The chronically swollen painful extremity

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doi: 10.1186/s12302-024-01044-y

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doi: 10.1007/s00441-002-0678-9 36 MurphyKGAbbottCRMahmoudiMHunterRGardinerJVRossiMet al

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Long-acting peptides GLP-1, dual-agonist and triple-agonist peptides, and CJC-1295 with DAC only need re-dosing on a multi-day timescale

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As we found here that a short-term treatment with CB-839 in HFD-fed mice resulted in weight loss and iWAT browning, randomized controlled trials testing the efficacy of GLS inhibitors such as CB-839 in improving metabolic health would be interesting to explore

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