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25,26 Right upper quadrant abdominal pain, in theory, results from stretching of the Glisson's capsule by hepatomegaly as a consequence of the increasing intrahepatic volume occupied by the developing hepatic granulomas

Net flux through upper glycolytic reaction GPI flipped from close to 100% of glucose uptake towards F6P to more than 100% reversed, while lower glycolysis (GAP to lactate) became mainly supplied by PPP-derived GAP

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