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Reported subcutaneous PT-141 timeline Time after subQ dose 0-30 minutes What was reported Possible flushing

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Melanosis coli can be observed during endoscopic procedures that examine the large intestine, such as colonoscopy and sigmoidoscopy

Those authors concluded that dithiothreitol could induce the unfolded protein response and this would lead to an over-expression of the SPT LCB1 subunit mRNA, partially recovering its activity 75

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