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investigated Hachimijiogan (HJG), revealing its ability to induce neurite outgrowth in PC12 cells by acting as a nerve growth factor (NGF)

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The resulting NO accumulation exacerbates glutamate-induced neurotoxicity, contributing to neuronal ferroptosis (53)

16 Infection can also lead to prosthesis failure, but with appropriate surgical techniques and antibiotic practices these rates are only 2% to 3% (slightly higher in diabetics)

Conversely, controlled enhancement of fatty-acid oxidation [e.g., via peroxisome proliferator-activated receptor alpha (PPAR) signaling] can sometimes rescue T cell energetic capacity in low-glucose settings, highlighting a context-dependent, bidirectional role of lipid metabolism [139]

In that regard, autopsy studies have shown SARS-CoV samples and neuronal degeneration in the hypothalamus (Pal 2020)