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In the context of sepsis, GSH plays a multifaceted role in counteracting the oxidative stress and mitochondrial dysfunction that underlie organ failure and systemic inflammation

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S-(2-succinyl)glutathione was reported act as an alternative substrate to glutathione reductase to decrease NADPH levels and boost mitochondrial ROS and HIF-1 activation 33

Acta 1822 , 729736 (2012)

Yen-Ming Huang in Graduate Institute of Clinical Pharmacy of NTU for statistical consultation and analyses, and the Centers of Genomic and Precision Medicine, NTU, for support in pharmacological dabigatran concentration analysis

Golubeva AV, Joyce SA, Moloney G, Burokas A, Sherwin E, Arboleya S, et al