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Elevated levels of GSH are critical for the optimal function of GPx that utilizes GSH as a substrate to neutralize H 2 O 2 and lipid hydroperoxides (41)

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Prdx6 reduces phospholipid hydroperoxides using GSH, and also the GST P1-1 class showed the ability to act as phospholipase A 2 [192]

& Baier, G

Oncogene 15 : 347360 Denecker G, Vercammen D, Steemans M, Vanden Berghe T, Brouckaert G, Van Loo G, Zhivotovsky B, Fiers W, Grooten J, Declercq W and Vandenabeele P (2001) Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

The possible allosteric effect of reactive oxygen species on GPx enzyme can lead to an increased activity through increased lipid peroxidation ( Reference Levin, Cogan and Levy 40 )