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Although direct clinical evidence for their pulmonary protective effects is still accumulating, meta-analyses of large cardiovascular outcome trials indicate that SGLT-2 inhibitors significantly reduce the risk of acute exacerbations in diabetic patients with comorbid COPD (Foer et al., 2023), suggesting that they provide a pleiotropic organ protection beyond hypoglycemic effects

These are sources of decomposition reaction in the form of lipid peroxidation, in which a single initiating free radical can precipitate the destruction of adjacent molecules

Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria

Schelhas C

Jonsson, T

The list that links the ID number to the randomisation code is kept with the company that produces the intervention and the placebo, and with the scientist who generated it who is otherwise not involved in the study