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Butyrate, a SCFA derived from probiotic metabolism, downregulates the transcription factor RORt in Th17 cells, curtailing IL-17A secretion a key driver of lupus nephritis considerably lowering pro-inflammatory cytokines like TNF- and IL-6 (146) ( Table 2 )

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Cuellar AK, Johnson SL, Winters R

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Together, they could therefore cover a wider spectrum against oxidative stress