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In vitro, Hypo-Exos suppressed LPS-induced proinflammatory cytokine release and reduced ROS in activated microglia, consistent with their role in promoting M2 macrophage polarization [42]

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Although these secretions have been proposed to fine-tune synaptic transmission and support neuronal metabolism, the precise mechanisms and physiological relevance of gliotransmission remain a matter of active debate 15,16,17

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