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To enhance the stability and bioavailability of EGCG, the prodrug of EGCG (pro-EGCG, EGCG octaacetate) could be useful [71,131]

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Furthermore, resveratrol (RES), -glucan-chitosan nanoparticles (DS-CS NPs), and resveratrol-loaded sulfated -glucan-chitosan nanoparticles (DS-CS-RES NPs) could inhibit the release of NO, as well as the protein levels of NF-B, p65, STAT 1, and TLR 4, along with the secretion of inflammatory mediators such as TNF- , IL-6, and IL-1 in LPS-induced RAW 264.7 macrophages

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So, these multicompartment models were developed to explain and also to predict the plasma and tissue concentrations of these drugs

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