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L., Leiferman, K

However, ZIP1 + fibroblasts have the ability to serve as zinc reservoirs, allowing the transfer of zinc from fibroblasts into tumor cells, and leading to the induction of ABCB1-mediated drug efflux and chemoresistance

However, the journey from bench to bedside has revealed both triumphs and tribulations, necessitating a critical synthesis of current knowledge and a roadmap for future innovation

doi: 10.1016/j.mrgentox.2013.03.014 43

Douer D, Watkins K, Louie R, Weitz I, Mohrbacher A, Levine AM

The major heme iron-dependent enzymes are the cytochromes of the oxidative phosphorylation pathway, soluble guanylate cyclase involved in the function of nitric oxide (NO), the anti-oxidant enzyme catalase, and the multiple members of the cytochrome P450 family of xenobiotic metabolizing enzymes found in the liver