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An investigation from Farshbaf-Khalili et al., in Iran (2022), in a triple-blind, randomized controlled trial, examined the effects of curcumin on oxidative stress markers in postmenopausal women 4060 years of age

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To establish a connection with the NO-system, l-NAME (5 mg/kg intraperitoneally) (worsening) and/or L-arginine (100 mg/kg intraperitoneally) (beneficial effect) were given alone or together

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[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Zeng A., Wei Z., Rabinovsky R., Jun H.J., El Fatimy R., Deforzh E., Arora R., Yao Y., Yao S., Yan W., et al

found that a substance called dehydroabietic acid binds to Keap1, activates NRF2-ARE, induces downstream gene expression, which in turn upregulates GSH, GPX4, inhibits ROS accumulation and lipid peroxidation, suppresses ferroptosis and NAFLD [148]