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Ochiai, K

10.1016/j.xcrm.2022.100790 164

Frontiers in Pharmacology, 12 , 627533

The absence or presence of publication bias was confirmed through the Eggers test, as shown in Table 1

Dietary triggers: Spicy foods, alcohol, and hot beverages can exacerbate symptoms

Gliotoxin can target integrins to modify their cysteines by a disulfide bond, thus blocking the binding of arginine-glysine-aspartic acid (RGD)-containing extracellular matrix, leading to the inhibition of focal adhesion kinase and the dephosphorylation of p190RhoGAP, which allows for the activation of RhoA and, subsequently, the activation of ROCK, MKK47/MKK7, and JNK and the induction of Bim phosphorylation, which is a proapoptotic factor