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In the POLLUX clinical trial, patients with relapsed or refractory multiple myeloma who received the combination of the anti-CD38 antibody daratumumab with lenalidomide and dexamethasone had significantly prolonged progression-free survival (PFS) relative to those who received lenalidomide and dexamethasone alone

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The gut microbiota also plays a significant role in late-phase oral NR metabolism (3 h post-administration), which is converted to NAM by the enzyme BST1, and then deamidated into NA by microbes, allowing PreissHandler synthesis by capable tissues 127