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It's just demonstrably less effective
J Australas Coll Nutr Environ Med
doi: 10.1111/acel.13781 157 MooreA
M.ParimonT.CusackB
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Because administration of desmopressin acetate can been associated with decreased responsiveness with prolonged use, consider increasing the dosage of DDAVP Nasal Spray if patients demonstrate decreased response over a long period of time
