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Definition of the role of melatonin in the patho-physiological mechanisms of inflammation has also been a growing research field

OXY could suppress the synthesis of pro-inflammatory mediators in microglia triggered by lipopolysaccharides (LPS) in mouse brain via interaction with mitogen-activated protein kinases (MAPKs) pathway and inhibition of the LPS-stimulated secretion of TNF- and IL-1 in these microglial cells (Yuan et al., 2016)

Cell Mol Bioeng

Additionally, co-administration of probiotics with standard treatments, such as surgery, chemotherapy, and immunotherapy, may help ameliorate treatment-associated adverse events, augment therapeutic efficacy, and improve overall patient quality of life

[DOI] [PubMed] [Google Scholar] 85.Cossart P., Helenius A

The results showed improvements in motor symptoms and dyskinesia