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Researchers have administered folic acid to rats exposed to large amounts of alcohol

doi: 10.1089/jmf.2019.4603 138 LeeD

Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway

Gillett HR, Arnott IDR, McIntyre M, et al
Higher doses dont necessarily improve results and may increase the risk of side effects

This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse
