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SOD1 oxidized at tryptophan (Trp32) was found to accumulate in the microsomal fractions purified from spinal cord of transgenic mice expressing wild-type human SOD1 [42] and was also detected in human blood and the blood isolated from transgenic mice expressing wild-type or ALS-linked mutant human SOD1 [106]

Currently on FDA Category 2 with a PCAC review scheduled for July 2026

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Ilic S, Drmic D, Franjic S, Kolenc D, Coric M, Brcic L, et al

Biochemical Society Transactions

Tajiri, M

Also note that high intake of folic acid can mask B12 deficiency and exacerbate anemia