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Zhou [12] demonstrated that oxidative stress in pregnancy can increase, even if the exact either pro-oxidant or antioxidant status in pregnancy-induced hypertensive patients is not clear [13]

FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

doi: 10.3389/fvets.2023.1220213 Received 15 May 2023 Accepted 17 July 2023 Published 10 August 2023 Volume 10 - 2023 Edited by Huansheng Yang, Hunan Normal University, China Reviewed by Dan Yi, Wuhan Polytechnic University, China