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G6PD is negatively regulated by acetylation on lysine 403 (Lys403), an evolutionarily conserved residue

This dysfunction alone can induce neurodegeneration by promoting the accumulation of neurotoxic proteinaceous aggregates [76]

It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca ions

Abstract The clinical translation of plant-derived anti-inflammatory agents is hindered by the disconnect between high-throughput in vitro assays and low-throughput, costly mammalian models

J Alzheimers Dis 59:481501 Mandel SA, Amit T, Weinreb O, Youdim MB (2011) Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases

En rduisant une inflammation excessive, il soutient un systme immunitaire quilibr et empche les impacts ngatifs des tats inflammatoires prolongs sur la sant globale