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Description
although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters ( MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)

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Dose Range: 212 mg weekly with gradual 4-week titration steps [3] [4]

Combine a healthy diet with targeted supplementation where necessary

Patients may hesitate before the first injection

GSH also helps remove toxins by forming GSH S-conjugates
