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Vitamin C is possibly unsafe when taken by mouth in excessive amounts

Large meals or high-fat meals exacerbate this, leading to nausea and discomfort

Getting B12 From Your Food When it comes to getting B12 naturally, your best sources are animal-based

(More information) Normal function of the digestive system required for food-bound vitamin B 12 absorption is commonly impaired in individuals over 60 years of age, placing them at risk for vitamin B 12 deficiency

This should be a control of the release of glutamate in the synaptic cleft from presynaptic terminals to stimulate post-synaptic neurons (i.e., the NMDA receptors) and re-uptake from the cleft by the excitatory amino acid transporters (EAAT) into astrocytes, and glutamate/glutamine cycle within astrocytes [59]