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Pouillot A, Dayan N, Polla AS, Polla LL, Polla BS

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Research continues to explore how circadian rhythm signaling peptides and proteins help regulate biological processes tied to sleep, temperature, and environmental cues

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According to the results of six randomized, double-blind, placebo-controlled clinical trials performed with Fragment 176-191, this peptide does not cause increases in IGF-1 levels, insulin resistance, impaired glucose tolerance, or any negative effect on carbohydrate metabolism [1]

For anyone exploring neuroprotective peptide strategies , understanding the BDNF-neurodegeneration connection is foundational