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43.Fernandes M, Majoni M, Garg AX, et al

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1 Introduction Chronic obstructive pulmonary disease (COPD) is a highly prevalent, progressive respiratory disorder characterized by persistent airway inflammation, irreversible airflow limitation, and alveolar destruction ( Emerging evidence now positions ferroptosis not merely as a consequence but as a key amplifier of COPD pathology, particularly through its dynamic interplay with immune dysregulation ( 2 Ferroptosis: a novel form of regulated cell death Ferroptosis is a distinctive type of regulated cell death that significantly differs from apoptosis, necrosis, and autophagy

Dominguez et al

& Kirchhoff, J

Moreover, they revealed that the mechanism by which RSV enhances the GSH system involves the AMPK signaling pathway, the Nrf2 signaling pathway, the Sirt1 pathway, noncoding RNA (miR-149) and the KAT5 gene [193,194,195,196,197]