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Genes Dev 21: 32143231 [DOI] [PubMed] [Google Scholar] Sierra J.R., Corso S., Caione L., Cepero V., Conrotto P., Cignetti A., et al

The goal is triggering the right cellular response, not flooding the system with excess peptide

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In turn, reduced tonic activation of presynaptic group II mGlu receptors disinhibits synaptic glutamate release, causing strengthened glutamatergic transmission at PFC-NAc synapses and disruption of several forms of synaptic plasticity (Moussawi et al., 2009)

Currently, therapeutic agents recommended for treating hypertriglyceridemia are fibrates, statins, niacin and omega-3 PUFA but others are being developed

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