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Access this article Similar content being viewed by others Data availability The data presented in this study are available on request from the corresponding author

In this article, we will review the recent advances in our understanding of HIV latency, review the approaches that are being tested as a means to cure HIV and discuss the challenges associated with targeting latently HIV-infected CD4 T cells for death, with a focus on ways to alter apoptosis regulation

It is well established that GPX4 is an attractive specific target for new pharmacological therapeutics aiming at activating cell death in cancer or inhibiting cell death in degenerative diseases

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