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The original patent documentation describes this mechanism in detail, noting that the peptide stimulates lipolysis and inhibits lipogenesis via beta-adrenergic signalling at concentrations far below those needed to activate growth-promoting pathways

Autophagy plays a key role in adipogenesis in adipose tissue, and dysregulated autophagy impairs fat accumulation [79]

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Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H, Hashimoto SI, Matsushima K (2002) Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system