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Glycine induces ferroptosis in RA-FLSs via S-adenosylmethionine (SAM)-associated methylation of GPX4 promoter, further enhancing ferroptosis efficacy by downregulating FTH1 expression

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Still, this does not preclude extramitochondrial CHAC1 from concurrently influencing ferroptosis, as we show that CHAC1 loss significantly spares cytosolic GSH under cystine starvation, a significant factor in the capacity of cells to mitigate lipid peroxidation 11