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As important factors for resisting oxidative stress and electrophile attack, nuclear factor erythroid 2-related factor 2 (Nrf2) and other antioxidant defense target genes can be transcriptionally promoted by -HB to prevent oxidative stress (Kolb et al., 2021)

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In patients with chest pain (n = 530) and acute coronary syndromes (ACS) (n = 1683), plasma levels of TMAO and its nutrient precursor TML could predict both the near-term (30-day/6-month) and long-term (17-year) risks of CV events (Senthong et al., 2016), heart failure (n = 720) (Tang et al., 2014) and peripheral artery disease (PAD) (n = 935) (Senthong et al., 2016), elevated TMAO levels could predict 5-year mortality and increased plasma TMAO levels were respectively associated with a 4-fold, 3.4-fold and 2.7-fold increased mortality risk

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