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This signaling cascade is the established mechanistic framework within which MT1 is investigated across independent research groups, though findings vary across experimental systems

Alternatively, lipids or cholesterol-derived metabolites downstream of muscular NCR-2 could be excreted and transported across tissues to influence neurons

J Neurooncol 146:417426 Hua H, Zhang X, Mu H, Meng Q, Jiang Y, Wang Y, Lu X, Wang A, Liu S, Zhang Y, Wan Z, Sun K (2018) RVG29-modified docetaxel-loaded nanoparticles for brain-targeted glioma therapy