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A multidisciplinary strategy that integrates biostatistics, machine learning, and sperm epigenome sequencing with clinical and lifestyle data may improve reproductive diagnostics and personalized treatment strategies (152)

Nofer JR, Junker R, Pulawski E, Fobker M, Levkau B, von Eckardstein A, Seedorf U, Assmann G, Walter M

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44 While there was no clear evidence of withdrawal hemolysis associated with the VOCs occurring during the clinical trials in SCD, a sudden stop in drug dosing due to noncompliance or side effects could theoretically translate into an abrupt increase in 2,3-DPG levels and a consequent shift of the oxygen dissociation curve to the right, promoting an acute increase in deoxy-HbS polymerization, sickling, and vaso-occlusion

To understand the role of regulatory NADH, the changes of number of conformation degree of freedom also measured after removing the regulatory NADH from the structure

Therefore, they are not an effective model for drug discovery model for mitochondrial pathologies