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These frequent arousals disrupt the continuity and depth of slow-wave sleep, reducing the restorative functions of sleep and further impairing glymphatic clearance of metabolic waste products, including ROS-generating aggregates such as beta-amyloid

Kelly S, Bakhireva L, Buresh C, Camenga D , Castaneda R, Kaliamurthy S, Smith D, Tolou-Shams M, Horigian V, Marsch L, Karnik N

Mitochondria play a critical role in intracellular Ca 2+ homeostasis and signal transduction ( 2+ through various Ca 2+ channels on the mitochondrial membrane

Fred Hutch/University of Washington/Seattle Childrens Cancer Consortium members Drs

Another large review of 12 studies found that vitamin E helped reduce blood sugar levels, while vitamin C was effective at decreasing levels of oxidative stress