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Curcumin is the most researched curcuminoid

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In agreement with these latter results, the work of Majors et al (1997) showed that a relatively low concentration of homocysteine (50 to 300 mol/L) stimulates collagen production in rabbit aortic smooth muscle cells that may favor extracellular matrix component accumulation in intimal lesions

10.1104/pp.125.4.2164 165 VuilleumierS

This antioxidant effect also enhances the activity of direct-acting antivirals such as telaprevir, especially in telaprevir-resistant replicon cells ( Beyond HCV, PYC also modulates host factors implicated in viral replication and immune regulation, including long non-coding IFN-induced protein-44 (lnc-IFI-44), polycystic kidney disease 1-like 3 (Pkd1l3), and ubiquitin-specific peptidase 31 (Usp31) ( PYC has also been reported to inhibit HIV-1 entry and replication ( Importantly, PYCs antiviral activity extends beyond direct viral inhibition to include complementary host-directed effects