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Signs of intramuscular injection include deeper, more intense pain during injection, increased bruising, faster onset of side effects (nausea, headache appearing within hours instead of the typical timeline), and a sore, tender feeling in the thigh muscle for a day or more after injection

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Upon receptor stimulation with agonist, G q and - subunits dissociate to initiate downstream effector pathways

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And tirzepatide is a dual incretin, which means it's GLP-1 and GLP